Biography

Naomi Gronich graduated medical school at Sackler School of Medicine, Tel Aviv University, and received her MD in 1998.
After completion of internal medicine residency at Meir Hospital, Kfar-Sava, she specialized in clinical pharmacology at the NIH (National Institute of Health), Maryland, USA.
In 2009, she joined the Department of Community Medicine and Epidemiology as part of the Personalized Medicine Unit, and the Carmel Medical Center Internal Medicine Department, both in Haifa.

Research Activities

• Studied the ß2f, a small ß subunit of the L-type calcium channel, in the human heart, by immunoprecipitation from human heart tissue and identification by mass spectrometry
• Studied the occurrence of ion channels splicing variations differences in human ischemic cardiomyopathy and healthy laser-captured microdissected myocytes, by splice microarray and real-time PCR
• Conducted and analyzed heart rate variability study in normal volunteers receiving physiologic stimulation and pharmacologic autonomic blockade
• Co-authored the study protocol and the Investigational New Drug (IND) application for the FDA (Food and Drug Administration) of a Phase 1 clinical study of R-R-fenoterol for the treatment of congestive heart failure
• Studied the correlation between ZAP70/CD38 levels and the cytogenetic aberrations (by FISH) in chronic lymphocytic leukemia patients
• Investigated the outcome of low grade non-Hodgkin's lymphoma patients with contradicting bone marrow results at diagnosis (negative morphologic appearance of the biopsy specimen and positive cytology of the aspirate)
• Studied the effect of simvastatin on multiple myeloma cell lines' various variables: viability, cell cycle, apoptotic measures, intracellular calcium concentration, IL-6 secretion and tyrosine phosphorylation activity

Keywords

Personalized medicine, pharmacogenetics, pharmacoepidemiology, pharmacogeriatrics

Publications

• Channels, Human cell-type specific gene expression screening of molecular remodeling in ischemic cardiomyopathy, Naomi Gronich, Azad Kumar, Yuwei Zhang, Igor R. Efimov & Nikolai M. Soldatov, 3-4/2010,4:1-7
• Saunders - Elsevier, Pharmacology and Therapeutics: Principles to Practice, by Scott Waldman and Andre Terzic (textbook), Pharmacology Across the Aging Continuum, Naomi Gronich, Darrell R. Abernethy, Chapter19, 2009
• Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, HPLC-atmospheric pressure chemical ionization mass spectrometric method for enantioselective determination of R, S-propranolol and R, S-hyoscyamine in human plasma, Danuta Siluk, Donald E. Mager, Naomi Gronich, Darrell R. Abernethy, Irving W Wainer, 11/2007, 859: 213-221
• European Journal of Clinical Investigation, Clinical outcome of low-grade NHL patients with bone marrow involvement, Naomi Gronich, Judith Radnay, Hava Shapiro, Yosef Manor, Meir Lahav, Michael Lishner, 4/2007, 37: 305-309
• European Journal of Internal Medicine, Factors influencing selection of internal medicine residency - a prospective study, David Pereg, Naomi Gronich, Michael Lishner, 8/2006, 17: 319-321
• Cancer Genetics and Cytogenetics, The influence of different chromosomal aberrations on molecular cytogenetic parameters in chronic lymphocytic leukemia, Aliza Amiel, Liat Leopold, Naomi Gronich, Mona Yukla, Moshe Fejgin, Michael Lishner, 1/2006, 167: 145-149
• Cancer Genetics and Cytogenetics, Random aneuploidy in neoplastic and pre-neoplastic diseases, multiple myeloma, and monoclonal gammopathy, Aliza Amiel, Naomi Gronich, Mona Yukla, Sarit Suliman, Galia Josef, Elena Gaber, Gali Drori, Moshe Fejgin, Michael Lishner, 10/2005, 162: 78-81
• Journal of Investigative Medicine, Simvastatin induces death of multiple myeloma cell lines, Naomi Gronich, Liat Drucker, Hava Shapiro, Judith Radnay, Shai Yarkoni, Michael Lishner, 7/2004, 52: 335-344
Papers in Preparation
• Pharmacodynamic Model of Atropine Effects On Heart Rate Variability Using a Wavelet-Based Biomarker Of Vagal Tone, Naomi Gronich, Danuta Siluk, Kristen M. Gowan, Darrell R. Abernethy, Donald E. Mager
• Pharmacokinetic/Pharmacodynamic Analysis of the Effect of Angiotensin-Converting-Enzyme Insertion/Deletion Polymorphism on the Parasympathetic Contribution to the Human Heart Rate Variability, Naomi Gronich, Kristen M. Gowen, Danuta Siluk, Julian F. Thayer, John J. Sollers, Irving W. Wainer, Darrell R. Abernethy, Donald E. Mager

Presentations / Poster sessions

• American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Molecular Remodeling of Ion Channels in Human Atrial and Ventricular Myocytes Associated with Ischemic Cardiomyopathy, Naomi Gronich, Azad Kumar, Yuwei Zhang, Igor R. Efimov, Nikolai M. Soldatov. 3/2010
• Oral Presentation: Israeli Society of Clinical Pharmacology Annual Meeting, Human Cell Type Specific Gene Expression Screening of Molecular Remodeling in Ischemic Cardiomyopathy, Naomi Gronich, Azad Kumar, Yuwei Zhang, Igor R. Efimov, Nikolai M. Soldatov, 1/2010
• American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Molecular Remodeling of Ca2+ Channels in Human Cardiac Myocytes Affected by Ischemic Cardiomyopathy, Naomi Gronich, Yuwei Zhang, Azad Kumar, William J. Hucker, William H. Wood III, Kevin G. Becker, Igor R. Efimov, Nikolai M. Soldatov. Abstract at: Clinical Pharmacology and Therapeutics, 3/2008, 83 suppl 1: S82
• American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Pharmacodynamic Model of Atropine Effects on Heart Rate Variability Using a Wavelet- Based Biomarker of Vagal Tone, Donald E. Mager, Naomi Gronich, Kristen Gowan, Darrell R. Abernethy, 3/2007
• American Society for Pharmacology and Experimental Therapeutics Annual Meeting, Direct Identification of the Ca2+ Channel small Cavß2f subunit in human cardiac ventricular tissue, Naomi Gronich, Satya Saxena, Jo Beth Harry, Ling li, Darrell R. Abernethy, Nikolai M. Soldatov, 4/2006
• Oral Presentation: Israel Society of Internal Medicine, Simvastatin induces death of multiple myeloma cell lines, Naomi Gronich, 1/2003
• Oral Presentation: Israel Society of Hematology and Blood Transfusion, Simvastatin induces death of multiple myeloma cell lines, Naomi Gronich, 7/2002